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Monday, July 13, 2020 | History

7 edition of The Genetic basis of alcohol and drug actions found in the catalog.

The Genetic basis of alcohol and drug actions

  • 7 Want to read
  • 10 Currently reading

Published by Plenum Press in New York .
Written in English

    Subjects:
  • Pharmacogenetics -- Animal models,
  • Alcoholism -- Animal models,
  • Drug abuse -- Animal models,
  • Alcoholism -- Genetic aspects,
  • Drug abuse -- Genetic aspects,
  • Alcohol -- Physiological effects,
  • Alcoholism -- genetics,
  • Pharmacogenetics,
  • Substance Abuse -- genetics

  • Edition Notes

    Includes bibliographical references and index.

    Statementedited by John C. Crabbe, Jr. and R. Adron Harris.
    ContributionsCrabbe, John C., Harris, R. Adron.
    Classifications
    LC ClassificationsRM301.3.G45 G46 1991
    The Physical Object
    Paginationxvi, 383 p. :
    Number of Pages383
    ID Numbers
    Open LibraryOL1549341M
    ISBN 100306438682
    LC Control Number91028926

      AM By Amber Moore. New research has found a strong link between alcohol dependence and a genetic variation called copy number variations on chromosome 5q Previous studies have shown that genetics play a significant role in making a person dependent on alcohol or drugs. Experts say that these genetic traits are heritable. People with addiction lose control over their actions. They crave and seek out drugs, alcohol, or other substances no matter what the cost—even at the risk of damaging friendships, hurting .

    The one exception is the genetic defects found in certain East Asian populations in enzymes (e.g., alcohol and aldehyde dehydrogenases) that metabolize alcohol (Chen et al., ). These defects dramatically increase side effects of acute alcohol intake, thereby reducing the individual's vulnerability to .   The Genetics of Alcohol Use Disorder. To understand how the risk of AUD is passed down from generation to generation, scientists have examined genetics in family lineages to identify potential hereditary causes of this chronic disease. In , some of the first research on the genetics of alcohol abuse and addiction was published. Medical.

      Aim: The scientific viewpoint of genetic polymorphisms associated with risk of alcoholism and its adverse individual behavioural reactions is the main focus of this review. A complex syndrome like alcoholism and its idiosyncrasy may not be entirely understood on the basis of pathophysiological concept of neurotransmission alone. While neuropharmacology explains the mechanism behind . NIAAA has funded the Collaborative Studies on Genetics of Alcoholism (COGA) since , with the goal of identifying the specific genes that influence alcohol use disorder. In addition, NIAAA funds investigators’ research in this important field, and also has an in-house research emphasis on the interaction of genes and the environment.


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The Genetic basis of alcohol and drug actions Download PDF EPUB FB2

The Genetic Basis of Alcohol and Drug Actions Softcover reprint of the original 1st ed. Edition by J.C. Crabbe Jr. (Editor), R.A. Harris (Editor). The earliest application of these models to research on drug mechanisms was in the area of alcohol research. Mardones () reported successful selective breeding of rats preferring and not preferring to drink alcohol under various conditions of dietary deficiency, suggesting genetic control of alcohol.

ISBN: OCLC Number: Description: xvi, pages: illustrations ; 24 cm: Contents: The tools of pharmacogenetics / Gerald E. McClearn --Behavioral studies of genetic differences in alcohol action / Tamara J.

Phillips and John C. Crabbe --Neurochemical studies of genetic differences in alcohol action / Andrea M. Allan and R. Adron Harris --Electrophysiological.

The Genetic Basis of Alcohol and Drug Actions Gerald E. McClearn (auth.), John C. Crabbe Jr., R. Adron Harris (eds.) HISTORICAL BACKGROUND The use of genetic animal models in neuroscience and biomedical research is showing dramatic growth.

ISBN: OCLC Number: Description: 1 online resource (xvi, pages: illustrations: Contents: The tools of pharmacogenetics / Gerald E. McClearn --Behavioral studies of genetic differences in alcohol action / Tamara J. Phillips and John C.

Crabbe --Neurochemical studies of genetic differences in alcohol action / Andrea M. Allan and R. Adron Harris. Genetic Basis of Alcohol and Drug Actions, The by Crabbe, John C; Harris, R.

Adron. Download Book The Genetic Basis Of Alcohol And Drug Actions in PDF format. You can Read Online The Genetic Basis Of Alcohol And Drug Actions here in PDF, EPUB, Mobi or Docx formats.

The Genetic Basis Of Alcohol And Drug Actions Author: J.C. Crabbe Jr. ISBN: The Genetics of Alcohol and Other Drug Dependence Danielle M.

Dick, Ph.D., and Arpana Agrawal, Ph.D. Danielle M. Dick, Ph.D., is an assistant professor of psychiatry, psychology, and human genetics at the Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia.

Alcohol use disorder (AUD) is defined by several symptom criteria, which can be dissected further at the genetic level. Over the past several years, our understanding of the genetic factors influencing alcohol use and abuse has progressed tremendously; numerous loci have been implicated in different aspects of alcohol use.

However, even those with a high genetic risk to substance abuse must first be driven by a nonhereditary factor to do it. The catalyst that leads to alcohol abuse is very often an environmental factor, such as work-related stress.

In general, the more risk factors a person has, the greater the chance of developing an alcohol use disorder or. the genetic transmission of liability to other drugs of abuse.

Nonetheless, the evidence available suggests that, as in the case of alcohol, addiction to other psychoactive substances appears to run in families.

One study found evidence for familial aggrega-tion of drug use, based on family history obtained from individuals admitted for. A study conducted by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) reviewed much of the research on alcohol use disorder and a possible genetic contribution.

The study concluded that genetic factors account for percent of the variance among people who struggle with alcohol use disorder. Numerous large-scale twin studies have documented the importance of genetic influences on how much people use substances (alcohol, tobacco, other drugs) and the likelihood that users will develop problems (Verhulst et al., ).However, twin studies also robustly demonstrate that genetic influences affect multiple forms of substance use (alcohol, illicit drugs) as well as.

However, 69% of the total genetic variance on alcohol dependence, and 64% of the genetic variance on illicit drug dependence resulted from the genetic factor shared across externalizing psychopathology.

This finding indicates that much of the genetic predisposition to alcohol and other drug dependence is not specific to that disorder. Download The Genetic Basis Of Alcohol And Drug Actions ebook PDF or Read Online books in PDF, EPUB, and Mobi Format.

Click Download or Read Online button to The Genetic Basis Of Alcohol And Drug Actions book pdf for free now. The Genetic Basis Of Alcohol And Drug Actions.

Author: J.C. Crabbe Jr. ISBN: Genre: Medical File Size. Price, M. (, June). Genes matter in addiction. Monitor on Psychology, 39 (6). At least half of a person's susceptibility to drug addiction can be linked to genetic factors.

The diversity of pathologic effects of alcohol indicates that this drug exerts toxicity through multiple mechanisms, each of which can be modulated by different genetic variants. Twin studies have demonstrated that the amount of alcohol one consumes has a genetic influence.

Data from Phillips, T. and Crabbe, J. () in The Genetic Basis of Alcohol and Drug Actions (Crabbe, J. and Harris, R. A., eds), pp.Plenum Press. *parents of 85 parents of 87 score An early use of mutants was the demonstration that jimpy mice, deficient in brain cerebrosides and sulfatides, were deficient in [z-opioid.

models of alcohol’s effects and alcohol use have greatly advanced our understanding of the genetic basis of alcoholism, resulting in the identification of quantitative trait loci and allowing for targeted manipulation of candidate genes. Novel research approaches—for example, into epigenetic mechanisms of gene regulation—also are under way and undoubtedly will further clarify the genetic.

This volume provides an in-depth look at the genetic influences that contribute to the development of alcoholism. Part I: Epidemiologic Studies contains five chapters that examine the various approaches employed in the study of the genetics of alcoholism.

It provides a historical perspective and details all the essentials of this subject. Research has shown that alcohol addiction is a complex disease, with both genetics and a tendency toward anxiety playing "crucial roles," writes researcher Subhash C.

The book includes an examination of sources of law important to addiction and its treatment. The foundations for forensic work in professional legal testimony is explored (e.g., legal system, case law precedent, statutes governing addictions, civil and criminal procedures).

The science of addiction is featured including the biology of addiction, addiction as a brain disease, responsibility vs.Dunwiddie T.V. () Electrophysiological Studies of Genetic Differences in Alcohol Action. In: Crabbe J.C., Harris R.A.

(eds) The Genetic Basis of Alcohol and Drug Actions. Springer, Boston, MA.